What oxygen partial pressure indicates readiness for ventilator weaning and extubation?

The reference standard for arterial partial pressure of oxygen (PaO₂) when weaning off a ventilator is ≥60 mmHg while the inspired oxygen concentration is ≤40%. This indicator reflects the body's oxygenation function and serves as an important criterion for extubation, but must be evaluated in conjunction with the patient’s overall clinical condition. If the PaO₂ remains persistently below this threshold or respiratory failure worsens, prompt medical evaluation and adjustment of treatment are recommended.

Oxygen partial pressure is a key parameter for assessing pulmonary gas exchange function. Achieving the above-mentioned standard indicates that the patient’s lungs can effectively take in oxygen even with low supplemental oxygen, meeting the body's metabolic demands and forming a basic prerequisite for independent breathing after ventilator withdrawal.

Extubation decisions should not rely solely on PaO₂ values; comprehensive assessment must also include the patient’s spontaneous breathing capacity, level of consciousness, and ability to clear airway secretions. Even if PaO₂ meets the standard, extubation should still be delayed if the patient exhibits shallow and rapid breathing, altered mental status, or ineffective sputum clearance.

Prior to extubation, ventilator support settings should be gradually reduced to strengthen spontaneous breathing. After extubation, ensure airway patency, continuously monitor blood oxygen saturation, provide warmed and humidified oxygen, encourage effective coughing and sputum expectoration, avoid cold exposure or irritants, and promote recovery of respiratory function.