What are the differences between Jiuyi Zhenxin Granules and Guipi Pills?
Dec 09, 2025
Source: Cainiu Health
Dr. Sun Lianqing
Introduction
Although both Jiuyi Zhenxin Granules and Guipi Pills are traditional Chinese patent medicines, there are significant differences between them, generally including core functions, primary indications, medicinal ingredients, pharmacological properties, and applicable populations. The core function of Jiuyi Zhenxin Granules is nourishing the heart and calming the mind, as well as invigorating qi and strengthening the spleen, with an emphasis on soothing the mind and relieving emotional discomfort. In contrast, the core function of Guipi Pills is invigorating qi and strengthening the spleen, and nourishing blood to calm the mind, focusing primarily on replenishing qi and blood.
Although both Jiowei Zhenxin Granules and Guipi Pills are traditional Chinese medicines, there are significant differences between them, generally including core functions, indications, medicinal ingredients, properties, and target populations. A detailed analysis is as follows:
1. Core Efficacy: The core function of Jiowei Zhenxin Granules is nourishing the heart and calming the mind, along with invigorating qi and strengthening the spleen. It primarily focuses on calming the mind and relieving emotional discomfort. In contrast, Guipi Pills mainly strengthen qi and the spleen, nourish blood, and calm the mind, emphasizing replenishment of qi and blood while simultaneously supporting the spleen and nourishing blood.
2. Indications: Jiowei Zhenxin Granules are primarily used for symptoms caused by deficiency of both the heart and spleen, such as excessive thinking, insomnia with vivid dreams, palpitations, and fatigue. Guipi Pills are mainly indicated for conditions due to heart-spleen deficiency and insufficient qi and blood, including shortness of breath, palpitations, insomnia, poor memory, dizziness, vertigo, and poor appetite.
3. Medicinal Ingredients: Jiowei Zhenxin Granules contain ingredients such as ginseng, sour jujube seed (Ziziphi Spinosae Semen), and Schisandra fruit (Schisandrae Chinensis Fructus), with a prominent proportion of herbs that calm the mind. Guipi Pills contain Codonopsis root (Dangshen), white atractylodes rhizome (Baizhu), astragalus root (Huangqi), and Chinese angelica (Danggui), placing greater emphasis on herbs that tonify qi and blood and strengthen the spleen.
4. Properties: Jiowei Zhenxin Granules have a balanced nature, with a more direct effect on calming the mind, making them particularly effective for discomfort caused by emotional fluctuations. Guipi Pills have a slightly warming nature and provide stronger tonic effects, making them suitable for long-term use in individuals with chronic deficiencies of qi and blood.
5. Target Populations: Jiowei Zhenxin Granules are better suited for individuals experiencing insomnia and excessive thinking due to high stress or anxiety. Guipi Pills are more appropriate for those with weak constitutions, deficiency of qi and blood, and accompanying symptoms of weakened spleen-stomach function and poor appetite.
Both medications should be selected based on proper pattern differentiation; blind substitution should be avoided. Dosage must follow instructions provided in the package insert or as directed by a physician—do not adjust dosage independently. If symptoms do not improve after taking the medication, promptly review and adjust the treatment plan.
