Can I take a nucleic acid test after drinking one or two ounces of white liquor?

Dec 09, 2025 Source: Cainiu Health
Dr. Huang Yuhong
Introduction
It is not recommended to undergo a nucleic acid test after drinking one or two ounces of liquor, as alcohol may interfere with the accuracy of the test results and affect cooperation during sample collection, increasing the risk of testing errors. If sampling has already been completed after drinking, or if any discomfort occurs after testing, it is advisable to seek medical consultation promptly. The core of nucleic acid testing is collecting viral nucleic acids from respiratory samples.

It is not recommended to undergo nucleic acid testing after consuming one liang (approximately 50 grams) of baijiu (Chinese white liquor), as alcohol may interfere with the accuracy of test results and affect cooperation during sample collection, increasing the risk of detection errors. If sampling has already been completed after drinking, or if discomfort occurs after testing, it is advisable to seek medical advice promptly.

The core of nucleic acid testing lies in collecting viral genetic material from respiratory samples. Alcohol is volatile, and after drinking, some of it is exhaled through the respiratory tract, potentially damaging the nucleic acid structure in the sample and leading to false-negative results, thereby affecting accurate assessment of infection status.

Meanwhile, the alcohol in baijiu can irritate the pharyngeal mucosa, possibly triggering coughing or nausea. This makes it difficult to cooperate with healthcare personnel during sampling, resulting in improper sample collection and further reducing the reliability of test results. Additionally, fluctuations in physical condition after drinking may indirectly affect physiological indicators related to testing.

To ensure accurate results, avoid drinking alcohol within 24 hours before sample collection, and also refrain from smoking or chewing gum to maintain oral hygiene. Avoid eating large amounts of food two hours prior to testing to prevent vomiting during sampling. Stay calm and cooperate fully during the procedure to ensure proper sample collection and improve testing accuracy.