Can I get the hepatitis B vaccine on Tuesday if I received the COVID-19 vaccine on Saturday?

Dec 09, 2025 Source: Cainiu Health
Dr. Huang Yuhong
Introduction
In addition, adverse reactions such as fever, fatigue, and local redness and swelling may occur after vaccination. If the interval between vaccines is too short, it becomes difficult to determine which vaccine caused the reaction, hindering timely assessment and management. In urgent situations, such as potential exposure to hepatitis B, professional evaluation should be conducted to weigh the risks and decide whether early vaccination is warranted. For non-urgent cases, the recommended intervals must be strictly followed.

Under normal circumstances, if you receive a COVID-19 vaccine on Saturday, it is not recommended to receive the hepatitis B vaccine on Tuesday, as the interval between the two vaccines is less than 14 days. Unless there is an emergency, the hepatitis B vaccination should be postponed. If you have any concerns, please consult healthcare professionals at the vaccination site. Detailed explanations are as follows:

Both the COVID-19 and hepatitis B vaccines require stimulating the body's immune response. A short interval between them may compromise the effectiveness of both vaccines. When the immune system is stimulated repeatedly within a short period, it may produce insufficient antibodies, failing to achieve optimal protection and reducing the overall benefit of vaccination.

In addition, common post-vaccination side effects such as fever, fatigue, and local redness or swelling may occur. If the interval between vaccines is too short, it becomes difficult to determine which vaccine caused the reaction, complicating timely assessment and management. In urgent situations, such as potential exposure to hepatitis B, early vaccination may be considered after professional evaluation and risk-benefit analysis. However, in non-emergency cases, the recommended minimum interval must be strictly followed.

Before vaccination, actively inform the healthcare provider about your recent vaccination history; ensure at least a 14-day gap between vaccines unless under emergency circumstances; remain under observation for 30 minutes after vaccination and closely monitor any physical reactions.