What is the postprandial blood glucose standard for individuals with hepatic and renal insufficiency?

Generally, postprandial blood glucose targets for individuals with impaired liver or kidney function should be individually adjusted. It is usually recommended to maintain levels between 7.8 and 11.1 mmol/L, with slightly higher targets allowed for more severe cases. If in doubt, it is advisable to consult a healthcare provider in advance. Detailed analysis is as follows:

In patients with kidney dysfunction, impaired excretion of metabolic waste can affect insulin sensitivity and reduce blood glucose regulation capacity. Postprandial glucose targets may therefore be adjusted according to the stage of kidney disease. For mild impairment, standard glucose control goals may apply; however, for moderate to severe cases, avoiding hypoglycemia takes priority, allowing for moderately higher blood glucose levels to prevent complications associated with overly strict glycemic control. In those with liver dysfunction, abnormal glycogen synthesis and breakdown in the liver lead to greater blood glucose fluctuations. Glucose management must consider the liver’s metabolic capacity, aiming to avoid both hyperglycemia and hypoglycemia.

Individual variations in clinical condition also influence target setting. For patients with liver or kidney dysfunction who also have diabetes, stricter glucose control is often needed to prevent further organ damage from chronic hyperglycemia. Conversely, in those without diabetes but with severe organ impairment, targets may be relaxed to support basic metabolic needs. Additionally, factors such as medication use and nutritional status can impact optimal glucose control, requiring comprehensive evaluation for personalized management.

Regular monitoring of blood glucose and organ function is essential for individuals with liver or kidney insufficiency. Blood glucose management plans should be established by physicians based on individual clinical conditions. Patients should follow dietary and medication guidance carefully, avoid self-adjusting treatment regimens, and seek medical attention promptly if experiencing abnormal blood glucose levels or physical discomfort.