Why do I have diarrhea after taking Zhibai Dihuang Pills?

Dec 10, 2025 Source: Cainiu Health
Dr. Huang Yuhong
Introduction
Diarrhea after taking Zhibai Dihuang Pills is mainly related to the cold and cool properties of the medicine irritating the gastrointestinal tract, individual spleen and stomach deficiency, improper dosage, allergic reactions, or inappropriate dietary combinations. If diarrhea occurs frequently, accompanied by abdominal pain or signs of dehydration, prompt medical attention is required. Ingredients in Zhibai Dihuang Pills such as Anemarrhena rhizome (Zhimu) and Phellodendron bark (Huangbai) are inherently cold in nature; individuals with sensitive spleen and stomach may experience irritation of the gastrointestinal mucosa after taking them.

Diarrhea after taking Zhibai Dihuang Pills is mainly related to the drug's cold and cool properties irritating the gastrointestinal tract, individual spleen and stomach deficiency, improper dosage, allergic reactions, and unreasonable dietary combinations. If diarrhea occurs frequently or is accompanied by abdominal pain or dehydration symptoms, medical attention should be sought promptly.

1. Gastrointestinal irritation due to the drug's cold nature: Components in Zhibai Dihuang Pills such as Anemarrhena (Zhimu) and Phellodendron (Huangbai) are inherently cold in nature. In individuals with sensitive spleen and stomach, these components may easily irritate the gastrointestinal mucosa, accelerate intestinal motility, and lead to discomforts such as diarrhea and bloating.

2. Individual spleen and stomach weakness: People with weak spleen and stomach functions already have poor digestive capacity. Cold-natured medications further damage the yang energy of the spleen and stomach, impairing digestion and transformation of food and fluids, resulting in symptoms such as diarrhea and loose stools.

3. Improper medication dosage: Excessive intake increases the metabolic burden on the gastrointestinal system. Accumulation of cold-natured ingredients in the body may exceed the gut’s tolerance, triggering diarrhea.

4. Allergic reaction: A small number of people may be allergic to certain ingredients in the medication. Besides diarrhea, symptoms may include rashes and itching. Allergy-induced congestion and edema of the intestinal mucosa can lead to abnormal bowel movements.

5. Unreasonable diet: Consuming raw, cold, greasy, or spicy foods during treatment may compound the drug’s cooling effects, irritate the gastrointestinal tract, disrupt the balance of normal intestinal flora, and trigger diarrhea.

During episodes of diarrhea, discontinue the medication temporarily, drink warm water to replenish fluids, choose warm and easily digestible foods to reduce gastrointestinal burden, keep the abdomen warm to avoid chilling, minimize exposure to cold stimuli, and support gradual recovery of intestinal function.