Does receiving the bivalent vaccine affect nucleic acid testing?

Generally speaking, "bivalent" usually refers to the bivalent HPV vaccine. Whether receiving the bivalent HPV vaccine affects nucleic acid testing depends on the specific type of test being performed. The detailed analysis is as follows:

When undergoing nucleic acid testing for the novel coronavirus (SARS-CoV-2), receiving the bivalent HPV vaccine typically has no impact and does not interfere with normal detection. The bivalent HPV vaccine targets human papillomavirus (HPV) and is unrelated to the novel coronavirus. Its components do not interfere with the primer design or detection process of SARS-CoV-2 nucleic acid tests, nor do they cause false-positive or false-negative results. Therefore, individuals can undergo SARS-CoV-2 nucleic acid testing at any time after vaccination.

If nucleic acid testing for HPV virus is required, it is generally not recommended to perform the test immediately after vaccination, as this may affect the accuracy of results. The vaccine stimulates the body to produce HPV-related antibodies, and in the short term following vaccination, HPV nucleic acid testing may yield false-negative results, failing to accurately reflect actual HPV infection status. It is therefore advisable to wait 1–2 months after completing vaccination before undergoing HPV nucleic acid testing.

After vaccination, keep the injection site clean and dry, and avoid contact with water for 24 hours to prevent infection. Avoid overeating before testing. During nucleic acid sampling, cooperate with healthcare personnel's instructions, maintain hand hygiene afterward, and if redness, swelling, or pain occurs at the injection site, apply cold compresses appropriately to relieve discomfort.