What medicine should be taken for mouth ulcers or blisters on the tongue caused by excessive internal heat?

Dec 12, 2025 Source: Cainiu Health
Dr. Sun Lianqing
Introduction
In general, mouth ulcers or blisters on the tongue are often associated with bacterial infection, viral invasion, or excessive internal heat. Common symptoms include local pain, redness, swelling, and difficulty eating. Patients may follow medical advice to use medications such as watermelon frost spray, Coptis chinensis tablets, acyclovir tablets, metronidazole mouthwash, and vitamin B2 tablets for treatment. A detailed analysis is as follows:

Generally, blisters on the tongue caused by "excessive internal heat" are often related to bacterial infections, viral invasion, or excessive internal heat. Common symptoms include local pain, swelling, and difficulty eating. Patients may follow medical advice to use medications such as watermelon frost spray, Coptis Chinensis & Upper Excess-Heat Tablets (Huanglian Shangqing Pian), acyclovir tablets, metronidazole mouthwash, and vitamin B2 tablets for treatment. Specific details are as follows:

1. Watermelon Frost Spray

Watermelon frost spray contains ingredients such as watermelon frost and coptis, which have effects of clearing heat, detoxifying, reducing swelling, and relieving pain. Applied directly to the blistered area, it helps alleviate local inflammatory reactions, reduce pain, and promote mucosal healing. It is suitable for oral ulcers caused by internal heat.

2. Coptis Chinensis & Upper Excess-Heat Tablets (Huanglian Shangqing Pian)

This is a heat-clearing and fire-purging medication containing coptis, skullcap, and other ingredients. It improves symptoms by clearing heat and toxins from the triple energizer. It is effective for tongue blisters, sore throat, and similar conditions caused by excessive internal heat, helping to regulate the body internally and reduce inflammatory irritation.

3. Acyclovir Tablets

Acyclovir is an antiviral drug that inhibits the replication of viruses such as herpes simplex virus. If tongue blisters are caused by a viral infection, taking acyclovir can prevent viral spread, shorten the duration of illness, and is particularly suitable for blister symptoms due to viral stomatitis.

4. Metronidazole Mouthwash

Metronidazole mouthwash has anti-anaerobic bacterial properties. By swishing the solution in the mouth, the medication comes into contact with the oral mucosa, suppressing the growth of harmful local bacteria, reducing inflammation caused by bacterial infection, and helping to relieve redness, swelling, and pain at the blister site.

5. Vitamin B2 Tablets

Vitamin B2 plays a role in cellular metabolism, and deficiency can easily lead to damage of the oral mucosa. Supplementing vitamin B2 promotes regeneration of mucosal cells and accelerates healing of blisters. It is suitable for tongue blisters caused by vitamin deficiency.

In daily life, maintain good oral hygiene, rinse your mouth after meals, and avoid consuming spicy or excessively hot foods such as hot pot, chili peppers, and strong alcohol to minimize irritation to the affected area and support recovery.