Can recombinant human interferon spray still be used after being stored in the refrigerator following opening?

Whether an opened recombinant human interferon spray can still be used after being continuously stored in the refrigerator depends on several factors, including the time since opening, storage conditions, and the physical condition of the medication. Details are as follows:

If the recombinant human interferon spray has been refrigerated after opening, and the time since opening has not exceeded the labeled post-opening expiration period, and if the solution remains clear without cloudiness or odor, with no damage to the bottle or nozzle, and the spray dispenses smoothly, then it may still be safely and effectively used. Refrigeration can inhibit microbial growth and help maintain drug stability for a certain period. As long as all the above conditions are met, the medication’s efficacy and safety can be assured.

However, if the time since opening exceeds the labeled usage period, or if the solution becomes cloudy, separates, develops sediment, or emits an unusual odor, the spray should not be used—even if it has been kept in the refrigerator continuously. Prolonged exposure after opening may lead to drug degradation, which even low temperatures cannot fully prevent. Microbial contamination may also occur. Using such compromised medication not only reduces therapeutic effectiveness but may also cause local irritation or increase the risk of infection due to spoiled liquid.

Proper storage of the recombinant human interferon spray after opening is essential. Always tightly close the cap immediately after each use to minimize exposure to air. When refrigerating, store it separately from food and other medications to avoid cross-contamination. Check the appearance of the solution before each use; discontinue and replace the product immediately if any abnormalities are observed. Regularly clean the nozzle to ensure it remains unblocked, thereby maintaining optimal performance, safety, and efficacy during use.