Is a single adenovirus vaccine shot administered nine months ago still effective?

Dec 12, 2025 Source: Cainiu Health
Dr. Li Feng
Introduction
Nine months ago, received one dose of adenovirus vaccine. After adenovirus vaccination, the body produces specific antibodies, which in most cases can persist for a relatively long time. Since nine months has not exceeded the typical protection period, the vaccine can still provide certain protective effects against the adenovirus types covered by the vaccine, reducing both the risk of infection and the severity of symptoms if infected.

Under normal circumstances, receiving an adenovirus vaccine nine months ago can still provide protection against specific types of adenovirus. However, the protective effect may decrease if the virus has mutated or if antibody levels are insufficient. If in doubt, it is advisable to consult a healthcare professional in advance. Detailed analysis is as follows:

After adenovirus vaccination, the body produces specific antibodies that typically remain in the system for a relatively long time. Nine months falls within the usual protection period; therefore, the vaccine can still offer certain defense against the adenovirus types it covers, reducing both the risk of infection and the severity of symptoms if infection occurs.

If circulating adenovirus strains have undergone significant mutations that differ from the types targeted by the vaccine, or if an individual's immune response leads to a rapid decline in antibody levels over time, the vaccine’s effectiveness may diminish. In such cases, it might not adequately protect against infection by variant viruses, and individuals could still develop symptoms after infection.

To determine whether the vaccine remains effective, consider the currently circulating virus strains and consult a healthcare provider to evaluate your antibody status. Meanwhile, maintain good personal hygiene practices, avoid crowded places, and take preventive measures to reduce the risk of infection.