What are the side effects of enteric-coated aspirin tablets?

Aug 04, 2026 Source: Cainiu Health
Dr. Tian Hongbo
Introduction
Common adverse effects of enteric-coated aspirin tablets primarily involve gastrointestinal injury, increased bleeding risk, neurological discomfort, allergic reactions, and abnormal liver or kidney function—most of which are associated with dosage and individual tolerance. If unusual physical discomfort occurs after long-term use, prompt medical consultation is required to adjust the treatment regimen. The drug may cause mild gastrointestinal irritation.

Common adverse effects of enteric-coated aspirin tablets primarily involve gastrointestinal injury, increased bleeding risk, neurological discomfort, allergic reactions, and hepatic or renal dysfunction—most of which are related to dosage and individual tolerance. If unusual physical discomfort occurs after long-term use, prompt medical consultation is essential to reassess and adjust the treatment regimen.

1. Gastrointestinal Injury: Aspirin mildly irritates the gastrointestinal mucosa; prolonged use may cause symptoms such as occult gastric pain, acid reflux, and abdominal distension. In some individuals, mucosal erosion may develop, impairing normal digestive function. Taking the medication on an empty stomach further exacerbates gastrointestinal irritation.

2. Increased Bleeding Risk: Aspirin inhibits platelet aggregation, and long-term use reduces coagulation capacity. This may manifest as gingival bleeding or skin ecchymosis; in severe cases, it may trigger gastrointestinal hemorrhage and adversely affect the body’s hemostatic mechanisms.

3. Neurological Discomfort: Prolonged excessive use may lead to dizziness, headache, tinnitus, sleep disturbances, or irritability. These neurological symptoms typically subside gradually upon dose reduction or discontinuation.

4. Systemic Allergic Reactions: A small proportion of individuals may experience pruritus or rash following administration. Highly sensitive individuals may develop mild peripheral edema; although severe allergic reactions are rare, they pose potential health risks.

5. Hepatic or Renal Dysfunction: Long-term continuous use slightly increases the metabolic burden on the liver and kidneys. A minority of patients may exhibit elevated transaminase levels or abnormal renal function parameters—usually transient and reversible, with organ function returning to baseline after discontinuation.

During treatment, maintain a light diet and regularly monitor your physical condition. Never adjust dosage or discontinue therapy without medical guidance. Adopt healthy lifestyle habits to minimize organ stress, and seek immediate medical attention should any abnormal symptoms arise.