What Are the Causes of Low Progesterone Levels?

Progesterone is a vital hormone in women’s bodies. Abnormal progesterone levels can significantly impair female fertility. Particularly during pregnancy, low progesterone levels greatly increase the risk of miscarriage; thus, women should closely monitor their progesterone status. So, what are the causes of low progesterone?

      Causes of Low Progesterone Levels

In women, low progesterone may result from adrenal insufficiency or thyroid dysfunction. Dysregulation of adrenal or thyroid function can profoundly affect the body and readily lead to ovarian dysfunction, thereby manifesting as low progesterone levels.

Women with hypertension or diabetes are also at increased risk for reduced progesterone levels. Hypertension and diabetes are common chronic conditions with substantial impacts on overall health. During pregnancy, gestational hypertension and gestational diabetes can readily cause a decline in circulating progesterone levels.

Luteal phase defect (LPD) is one of the most common causes of low progesterone. When the corpus luteum fails to function properly, it produces insufficient progesterone. If progesterone levels are low during pregnancy, prompt intervention is essential—otherwise, miscarriage may ensue. Pregnant women may be prescribed medication to rapidly restore normal progesterone levels.

Women diagnosed with low progesterone should take this seriously, as its adverse effects are significant and its underlying causes multifactorial. Clinical experience indicates that low progesterone may stem from inadequate development of the ovarian corpus luteum, luteal phase defect, certain systemic diseases, or unhealthy lifestyle habits.