How to Remove Wrinkles at the Corners of the Mouth

With the passage of time, wrinkles inevitably develop on everyone’s face. Particularly noticeable are perioral wrinkles—those around the mouth corners—which can make a person appear significantly older. How, then, can these corner-of-the-mouth wrinkles be effectively treated?

How to Remove Corner-of-the-Mouth Wrinkles

The primary treatment options for corner-of-the-mouth wrinkles include the following:

Botulinum toxin injection: Perioral wrinkles are dynamic in nature—i.e., they result from repeated muscular contractions. Injecting botulinum toxin reduces the activity range of the muscles around the mouth corners, thereby diminishing wrinkle formation. Hyaluronic acid (HA) injection: For deeper, long-standing wrinkles that cannot be fully smoothed with botulinum toxin alone, targeted filler injections—using either hyaluronic acid or autologous fat—can help restore volume and smooth out pronounced lines. However, caution is essential during filler administration: because perioral wrinkles tend to be relatively shallow, excessive filler volume may lead to visible ridges or raised, cord-like elevations, compromising aesthetic outcomes.

Other therapeutic approaches: Acupuncture may also be used to address perioral wrinkles. Alternatively, small-molecule hyaluronic acid can be injected to gently plump the local tissue. Combining this with low-dose botulinum toxin injections further enhances wrinkle reduction. Importantly, eliminating perioral wrinkles is not an immediate process—it requires consistent, scheduled clinical visits over time.

In daily life, rigorous sun protection is essential. Excessive facial expressions—such as frequent laughing or crying—can accelerate wrinkle formation around the mouth corners. Chronic sleep deprivation should also be avoided. Nutritionally, increasing intake of high-protein foods supports skin elasticity and overall dermal health. We hope this information proves helpful to you!