Can a positive liver fluke antibody test resolve spontaneously?

  A positive liver fluke antibody test generally does not resolve spontaneously.

  A positive liver fluke antibody result typically indicates prior infection with the liver fluke (Clonorchis sinensis). Even if adult worms have died, antibodies may remain detectable for a prolonged period. In such cases, spontaneous resolution is unlikely. Once liver flukes enter the human body, they parasitize the bile ducts and other locations, continuously absorbing nutrients from the host and damaging bile duct tissue. The human immune system alone is generally unable to completely eliminate the liver flukes and their eggs. Without antiparasitic treatment, persistent infection can lead to various pathological changes, including cholangitis, cholecystitis, and even progression to cirrhosis.

  However, it is important to note that a positive liver fluke antibody test only suggests a history of infection; definitive diagnosis of current active infection requires additional testing—such as stool examination—to detect viable eggs or adult worms. If live liver flukes are identified, treatment is necessary. Under a physician’s guidance, medications such as praziquantel tablets, albendazole tablets, and hepatoprotective agents may be prescribed to alleviate symptoms and prevent disease progression.

  In daily life, maintain a light, bland diet and avoid spicy or irritating foods—for example, garlic, spicy hotpot, and wasabi. Additionally, ensure adequate rest and avoid excessive physical exertion to safeguard overall health.