What Causes Cold Sores at the Corners of the Mouth?

Herpes is a common disease caused by the herpes virus. So, what causes herpes lesions at the corners of the mouth?

What Causes Herpes at the Corners of the Mouth?

Herpes lesions at the corners of the mouth are most commonly caused by infection with the herpes simplex virus (HSV)—specifically, oral herpes. Typically, HSV type 1 (HSV-1) is responsible for oral infections, whereas HSV type 2 (HSV-2) primarily causes genital herpes. Nevertheless, treatment approaches for both types are similar. In most cases, the condition is self-limiting, progressing naturally from vesicle formation to drying, crusting, and eventual shedding.

For faster recovery, early antiviral therapy can effectively suppress viral replication. Individuals with prior herpes episodes often experience prodromal symptoms—such as swelling, itching, or discomfort—before visible blisters appear. Initiating antiviral medications like acyclovir or famciclovir at this stage can rapidly inhibit viral activity and shorten the healing period.

Frequent occurrences of herpes at the corners of the mouth may be attributed to several factors: First, HSV infection may become active when an individual’s immune function declines—for instance, due to excessive mental stress or fatigue. In such cases, oral administration of antiviral agents such as valacyclovir tablets or acyclovir tablets is recommended, alongside maintaining regular dietary habits and avoiding late-night activities. Second, if internal heat-toxin accumulation or endocrine imbalance is suspected, traditional Chinese medicine (TCM) regulation may be beneficial. This approach can be combined with vitamin C supplementation and topical application of acyclovir cream for antiviral management. We hope this article has been helpful. Wishing you a joyful life and optimal health!