What Is Squamous Cell Carcinoma Antigen?
When undergoing medical examinations at a hospital, many people feel puzzled upon seeing “squamous cell carcinoma antigen” (SCC-Ag) listed in their test results. As this term is unfamiliar to most individuals, they often wonder: What exactly is squamous cell carcinoma antigen?
What Is Squamous Cell Carcinoma Antigen?
Squamous cell carcinoma antigen (SCC-Ag) is a tumor-associated glycoprotein found in the cytoplasm of squamous epithelial cells—particularly in non-keratinized cells—and is commonly expressed in tissues such as the head and neck, lungs, uterus, and cervix. Elevated serum SCC-Ag levels may be observed in patients with cervical cancer, pulmonary squamous cell carcinoma, skin cancer, head and neck cancers, gastrointestinal malignancies, and urological malignancies. Importantly, SCC-Ag levels often correlate closely with tumor aggressiveness and disease progression. Prior to treatment, SCC-Ag levels may be elevated; successful therapy typically leads to normalization of these levels. Conversely, recurrence or metastasis of cancer is frequently accompanied by a subsequent rise in SCC-Ag.
Elevated SCC-Ag levels are most commonly seen in patients with cervical cancer, pulmonary squamous cell carcinoma, and early-stage (Stage I) esophageal cancer. However, transiently elevated SCC-Ag may also occur due to non-malignant conditions such as inflammation or excessive physical or psychological stress. In such cases, clinicians generally recommend re-evaluation after 1–3 months.
Patients diagnosed with squamous cell carcinoma are encouraged to maintain a balanced diet rich in vitamins, proteins, healthy fats, and carbohydrates to bolster their immune function and enhance overall resistance to disease. Postoperative patients may benefit from foods such as goji berries, longan fruit, mulberries, Chinese yam, pork liver, sesame seeds, soft-shelled turtle, and squid. For those undergoing chemotherapy, dietary emphasis should be placed on spleen-strengthening and kidney-nourishing foods. We hope this information proves helpful!
