Adverse reactions to hyaluronic acid injections at the outer canthus

Both male and female patients aspire to enhance their facial appearance. When natural or non-invasive methods fail to achieve the desired aesthetic outcome, many turn to cosmetic medical treatments—such as hyaluronic acid (HA) injections—to attain their goals. While HA injections often yield satisfactory results, they may also cause certain adverse reactions. What, then, are the potential adverse reactions associated with HA injections around the eye area?

Adverse Reactions to Hyaluronic Acid Injections Around the Eye Area

Potential side effects of HA injections in the periorbital region include localized skin itching, pain, and infection. As individual constitutions vary, so do the local adverse reactions following HA injection. Generally, individuals with sensitive skin may develop allergic reactions—manifesting as pruritus (itching) and urticaria (hives). Moreover, those with compromised immunity or generally weaker physical constitution may be more susceptible to localized infection.

Hyaluronic acid is naturally present in various animal tissues, mucosal secretions, the crystalline lens of the eye, and human skin—where it exists in relatively high concentrations. In the skin, HA primarily functions to retain moisture, maintain hydration, and preserve skin elasticity. As a naturally occurring filler, hyaluronic acid exhibits excellent biocompatibility with human tissue. Clinically, HA is typically categorized into low-molecular-weight, medium-molecular-weight, and high-molecular-weight formulations. Low-molecular-weight HA is commonly used for repairing damaged skin and enhancing hydration and skin softness. The primary active ingredient in “hydrafacial” (or “water-light” needle) treatments is hyaluronic acid.

During the recovery period, special care must be taken around the eye area: avoid using irritating or low-quality skincare products, and refrain from rubbing or scratching the periorbital region, as such actions increase the risk of infection. We hope this information proves helpful to you!