When during the day is the best time to take folic acid?

May 16, 2022 Source: Cainiu Health
Dr. Chen Zhe
Introduction
It is optimal to begin folic acid supplementation during the preconception period; therefore, women can start taking folic acid three months before becoming pregnant. After conception, folic acid supplementation is typically continued for the first three months of pregnancy; however, if needed, it may be taken throughout the entire pregnancy. In general, folic acid tablets should be taken once daily. If a dose is missed on one day, there is no need to take a double dose the next day—simply resume the regular daily dosage, as long as overall folic acid intake remains adequate.

Supplementing with folic acid during pregnancy effectively helps prevent fetal developmental abnormalities. However, many women are uncertain about when to begin folic acid supplementation. So, what is the optimal time of day to take folic acid?

When Is the Best Time of Day to Take Folic Acid?

The ideal time to start folic acid supplementation is during the preconception period—ideally beginning three months before conception. After becoming pregnant, it is recommended to continue taking folic acid for at least the first trimester (three months). If needed, folic acid supplementation may be continued throughout pregnancy. Typically, folic acid tablets are taken once daily. If a dose is missed, there is no need to double the next dose; simply resume your regular schedule, provided overall intake remains adequate.

Some women experience unplanned pregnancies and therefore did not supplement with folic acid prior to conception. In such cases, there is no need for excessive concern—starting folic acid supplementation as soon as pregnancy is confirmed is still beneficial. Since the fetus relies entirely on maternal nutrient supply, inadequate maternal nutrition—including insufficient folic acid—may lead to anemia. Appropriate folic acid supplementation can effectively help prevent pregnancy-related anemia.

Currently, folic acid supplementation during pregnancy primarily aims to prevent neural tube defects (e.g., spina bifida) and orofacial clefts (e.g., cleft lip and palate) in the developing fetus. Adequate folic acid intake significantly reduces the risk of congenital anomalies in newborns. Insufficient maternal folic acid levels may also increase the risk of placental abruption—a potentially life-threatening condition for both mother and baby. Furthermore, folic acid deficiency can impair fetal growth and neurodevelopment. Therefore, pregnant women should ensure timely and appropriate folic acid supplementation. We hope this information is helpful to you!