AMH Normal Range

May 27, 2022 Source: Cainiu Health
Dr. Pan Yongyuan
Introduction
AMH (anti-Müllerian hormone) levels are clinically referred to as anti-Müllerian hormone, with a normal range of 2.0–6.8 ng/mL. AMH levels vary with age; older individuals typically exhibit relatively lower AMH levels. AMH is used to assess ovarian function in women: lower AMH levels indicate diminished ovarian function and may suggest premature ovarian insufficiency.

AMH (Anti-Müllerian Hormone) is a hormone secreted by Sertoli cells in the testes of males and granulosa cells in the ovaries of females. What, then, constitutes a normal AMH level?

Normal AMH Levels

Clinically, AMH is also referred to as anti-müllerian hormone (not anti-tyrosinase—this appears to be an error in the original text). A normal serum AMH concentration typically ranges from 2.0 to 6.8 ng/mL. AMH levels vary with age; older individuals generally exhibit lower AMH values. AMH serves as a key biomarker for ovarian function in women: lower AMH levels indicate diminished ovarian function and may suggest premature ovarian insufficiency (POI). In perimenopausal women, AMH levels fall below 2.0 ng/mL. Among women of reproductive age, AMH levels below the normal range reflect poor ovarian reserve and are associated with reduced likelihood of pregnancy. AMH levels exceeding 6.8 ng/mL may indicate polycystic ovary syndrome (PCOS); exceptionally high levels could also raise suspicion for granulosa cell tumor, warranting prompt pelvic ultrasound evaluation at a medical facility.

AMH, also known as anti-Müllerian hormone, is produced by granulosa cells of small antral follicles in the ovary. When ovarian function is robust, the number of antral follicles increases, leading to higher AMH levels. The reference range for AMH may vary slightly among laboratories, but most clinical laboratories define the normal range as 2–6.8 ng/mL.

Ovarian function declines with advancing age. Among women of the same age, a greater number of antral follicles correlates with better ovarian reserve. Within the normal reproductive age range, higher AMH values indicate a larger pool of antral follicles, whereas lower values suggest diminished ovarian reserve. We hope this information is helpful to you!

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