Does long-term use of Tripterygium wilfordii tablets have side effects?

Feb 24, 2022 Source: Cainiu Health
Disease description:

After visiting the hospital for a checkup, Grandma was diagnosed with rheumatoid arthritis. Her doctor prescribed some tripterygium tablets. Are there any adverse effects associated with long-term use of tripterygium tablets?

Doctor's answer (1)
Dr. Gao Zhaomeng
Common side effects of tripterygium wilfordii tablets include nausea, vomiting, gastrointestinal bleeding, and abdominal pain. Long-term use of tripterygium wilfordii may lead to decreased platelet, red blood cell, and white blood cell counts; patients often experience pallor and fatigue, and severe cases may progress to aplastic anemia. Additionally, this drug can impair the reproductive system, frequently causing amenorrhea and menstrual cycle disturbances in women. Upon experiencing any of these adverse effects, patients must discontinue the medication immediately; otherwise, irreversible damage to the body may occur.