Can patients with type 1 diabetes take metformin hydrochloride extended-release tablets?

Type 1 diabetes is an insulin-dependent form of diabetes, typically requiring insulin therapy to control blood glucose levels. Metformin hydrochloride extended-release tablets are primarily used for the treatment of type 2 diabetes; they lower blood glucose by reducing hepatic glucose production and enhancing insulin sensitivity. For patients with type 1 diabetes, metformin hydrochloride extended-release tablets are neither a first-line nor a standard treatment, as these patients generally lack endogenous insulin secretion and require exogenous insulin supplementation. However, in certain specific circumstances—such as concomitant insulin resistance or obesity—a physician may consider adding metformin as an adjunctive therapy. Therefore, patients with type 1 diabetes should use metformin hydrochloride extended-release tablets only under the guidance of a physician to ensure safety and efficacy.