What causes leg weakness and fatigue in leukemia?

Dec 22, 2022 Source: Cainiu Health
Disease description:

My grandfather has leukemia, and his face looks somewhat pale. However, for the past two days, he's been saying that his legs feel weak and lack strength. I'd like to know what might be causing this?

Doctor's answer (1)
Dr. Zhang Heyang
Leg weakness and fatigue in leukemia patients may be caused by anemia, usually resulting from bone marrow suppression. It could also be due to infiltration of the periosteum by leukemia cells, leading to lower limb pain. Additionally, if the patient's nervous system is damaged—such as the peripheral or central nervous system—this can also cause symptoms of leg weakness and fatigue.