What causes acute myeloid leukemia?
Disease description:
Fever, bleeding, and anemia, which may lead to infections and hyperuricemia
Acute myeloid leukemia may be caused by environmental factors, such as chemotherapy, radiation therapy, exposure to chemicals and harmful radiation, as well as a history of prior hematologic disorders, including myelodysplastic syndromes and myeloproliferative neoplasms, which can lead to the transformation into acute leukemia. Leukemic blasts escape immune surveillance and proliferate abnormally in the bone marrow, suppressing normal hematopoiesis and leading to the development of acute leukemia. Acute leukemia patients can be cured through chemotherapy, and some patients may achieve cure via hematopoietic stem cell transplantation.