The hypervariable region of immunoglobulin is located at
Disease description:
Hello doctor, I'd like to know what the hypervariable regions of immunoglobulins are. Our teacher mentioned this topic in class yesterday, but I didn't quite understand it. Could you please explain it to me? Thank you.
Doctor's answer (1)
Dr. Liu Aihua
The hypervariable region is a structural feature of antibody immunoglobulin (Ig), located at the terminus of the Ig protein, and consists of combinations of viral and transposon sequences known as V, D, and J segments. The V segment contains variable sites; each Ig receptor can undergo multiple recombination and splicing events to generate diverse proteins. The D and J segments are shared receptor sequences that function to join spliced V segment sequences into variable receptors. This diversity of Ig receptors enhances receptor specificity, enabling the detection of a broader range of pathogens and effectively defending against pathogen invasion.
