What are the causes of blocked blood vessels in the lower leg?

There are three main causes of leg blood vessel blockage. The first is increased platelet aggregation, which can elevate blood viscosity and lead to blockages within the vessels, potentially forming blood clots in severe cases. The second cause is thickening and hardening of the blood vessels, where new cells grow inside the vessel walls, causing them to thicken and stiffen, thereby impairing blood flow. The third cause is reduced platelet cohesion, meaning platelets cannot aggregate effectively, making it easier for blood clots to form and result in vessel blockage.