Does the quadrivalent influenza vaccine injection require air expulsion?

Exhausting air from the quadrivalent influenza vaccine injection is an important technique that helps reduce potential side effects following vaccination. Air exhaustion removes gases contained in the vaccine solution, allowing the excipients and surfactants in the vaccine to effectively protect the immune system. This process can minimize vaccine-related side effects such as fever, headache, weight loss, fatigue, and decreased resistance, thereby providing better immunogenicity for the recipient. During the air exhaustion process of the quadrivalent influenza vaccine, a certain amount of air is typically retained. This residual air can form a protective layer that helps inhibit viral replication and reduces adverse reactions after vaccination.