Causes and Risks of Elevated Indirect Bilirubin
Disease description:
Recently, I've been feeling constantly fatigued. My friends have noticed that my complexion is sallow and I appear lifeless, which seems abnormal. My doctor mentioned that my indirect bilirubin level is elevated. So I'd like to ask: what are the causes and potential risks of high indirect bilirubin?
Doctor's answer (1)
Dr. Gao Jun
Elevated indirect bilirubin levels are mainly caused by liver diseases such as acute icteric hepatitis and cirrhosis, which impair liver function and disrupt the normal metabolism of indirect bilirubin. Additionally, conditions like hemolytic anemia, incompatible blood transfusions, severe burns, and sepsis can also lead to increased indirect bilirubin.
Non-disease factors such as heavy alcohol consumption and long-term use of certain medications may also affect liver health, thereby causing elevated indirect bilirubin levels. The risks associated with persistently high indirect bilirubin should not be overlooked. Chronic elevation may damage the liver, leading to symptoms such as hepatic pain and loss of appetite.
At the same time, it may trigger hemolytic anemia, resulting in extensive destruction of red blood cells. In severe cases, it can also harm the kidneys and nervous system, manifesting as oliguria, anuria, proteinuria, drowsiness, or even coma. If any adverse symptoms occur, prompt medical attention is advised.
