Why does rheumatoid arthritis cause whole-body weakness?

Possible reasons for generalized weakness caused by rheumatoid arthritis may include the following: 1. Disease-related factors: Rheumatoid arthritis is a chronic systemic autoimmune disease. In severe cases, it may trigger inflammatory responses in the body, leading to feelings of generalized fatigue and weakness. 2. Medication side effects: During treatment, patients may be prescribed corticosteroids, biologic agents, or targeted drugs. Long-term use of these medications can lead to complications such as osteoporosis or disturbances in water and sodium metabolism, which may contribute to generalized weakness. 3. Other complications: Rheumatoid arthritis may also cause additional complications such as myositis (muscle inflammation) or hypoalbuminemia, both of which can result in systemic fatigue.