Effects of Glucocorticoids on Children's Growth and Development
Disease description:
My child has been coughing frequently, and the doctor recommended using inhaled corticosteroids via nebulization for treatment. I'm always worried that corticosteroids might affect my child's growth and development. What impact do corticosteroids have on children's growth and development?
Doctor's answer (1)
Dr. Zhou Xiaofeng
The impact of glucocorticoids on children's growth and development is manifested in several aspects:
1. Glucocorticoids may suppress the secretion of growth hormone, leading to delayed height growth in children, and even causing slowed or halted growth velocity.
2. Long-term use of glucocorticoids can inhibit osteoblast activity while promoting osteoclast function, resulting in decreased bone mineral density and an increased risk of fractures.
3. Glucocorticoids also promote fat synthesis and accumulation, leading to central obesity and affecting body composition in children. Additionally, they can suppress the hypothalamic-pituitary-adrenal (HPA) axis, potentially causing clinical manifestations such as adrenal insufficiency.
4. Glucocorticoids exert immunosuppressive effects, increasing the risk of infections in children.
When administering glucocorticoids to children, it is essential to closely monitor growth and developmental parameters and to use these medications appropriately under medical guidance.
