What is the situation in the late stage of chronic leukemia?

Chronic leukemia in the advanced stage refers to a more severe phase of the disease, during which patients typically develop a series of significant symptoms and complications. The specific manifestations include: 1. Prominent symptoms: Patients with advanced chronic leukemia often experience symptoms such as fatigue, anemia, bleeding tendency, enlarged lymph nodes, and splenomegaly. Anemia may lead to shortness of breath and palpitations, while bleeding tendency may manifest as skin bruising and gum bleeding. In severe cases, intracranial hemorrhage may even occur. 2. Frequent complications: Patients in the advanced stage are prone to severe secondary infections due to impaired immune systems. Additionally, secondary malignancies may develop as a result of immune deficiency or chemotherapy. Patients may also develop autoimmune disorders, such as autoimmune hemolytic anemia. 3. Limited survival duration: The life expectancy of patients with advanced chronic leukemia varies depending on individual factors, but it is generally measured in months to a few years. A patient's survival period may be influenced by multiple factors, including physical condition, complications, and response to treatment.