Can a woman with normal liver function and the "big three positive" (indicating chronic hepatitis B infection) become pregnant?
Disease description:
I was diagnosed with hepatitis B "big three positives" this year, but my liver function is normal. I would like to know if it is possible to get pregnant with normal liver function despite having the "big three positives."
Doctor's answer (1)
Dr. Yang Ziqi
Pregnancy is possible for patients with "Big Three Positive" (positive HBsAg, HBeAg, and HBcAb) and normal liver function, but the following points should be noted:
1. **Condition Assessment**: "Big Three Positive" indicates a state after hepatitis B virus infection. If liver function is normal, it suggests the patient is in the immune tolerance phase. However, liver function and hepatitis B virus DNA levels should still be monitored regularly.
2. **Mother-to-Child Transmission Prevention**: Since patients with "Big Three Positive" have active viral replication and high infectivity, starting from the 26th to 28th week of pregnancy, nucleotide analogs (such as telbivudine or tenofovir) should be considered orally to reduce viral load and decrease the risk of vertical transmission to the fetus.
3. **Partner Prevention**: If the spouse does not have hepatitis B surface antibodies, timely hepatitis B vaccination should be administered to prevent viral transmission through unprotected sexual contact.
4. **Regular Monitoring**: Liver function and hepatitis B virus DNA levels should be regularly rechecked during pregnancy to monitor any changes in the condition.
