Why does chronic gastroenteritis persist for a long time without improvement?

Chronic gastroenteritis that fails to improve over a long period may be caused by multiple factors: 1. Infectious factors: Viral or bacterial infections, such as chronic Shigella infection or intestinal tuberculosis, can continuously irritate the gastrointestinal mucosa, leading to recurrent inflammation. 2. Non-infectious intestinal diseases: Conditions such as Crohn's disease and ulcerative colitis can chronically affect gastrointestinal health, making it difficult for inflammation to resolve. 3. Medication factors: Certain medications, such as aspirin and selective COX-2 inhibitors, may damage the gastric mucosa and cause chronic inflammation. 4. Lifestyle factors: Irregular eating and sleeping habits, as well as prolonged mental stress and emotional tension, may all affect the treatment outcomes of chronic gastroenteritis. 5. Genetic factors: If there is a family history of chronic gastritis or enteritis, the risk of developing the condition may be higher for offspring.