What are the side effects of Rhizoma Acori Graminei on the kidneys?

The main side effects of *Acorus stone* (Shi Changpu) on the kidneys include the following: 1. **Nephrotoxicity**: Certain substances in Shi Changpu may damage the kidneys, leading to abnormal kidney function. Long-term or excessive use may increase the burden on the kidneys and cause adverse reactions such as limb edema. 2. **Exacerbation of underlying conditions**: For patients with pre-existing kidney disease, the use of Shi Changpu may worsen the condition, potentially leading to acute renal failure, which may progress to chronic kidney disease and impair long-term health. 3. **Systemic effects**: Shi Changpu may also cause other side effects, such as central nervous system depression, arrhythmia, gastrointestinal discomfort, and allergic reactions. These effects may indirectly impair kidney function. The kidney-related side effects of Shi Changpu should not be overlooked. Its use should follow medical advice, avoiding excessive or prolonged administration. Individuals should also monitor their physical responses and seek medical attention promptly if any abnormalities occur.