What are the early symptoms of myeloma?

The main early symptoms of myeloma include the following: 1. **Bone pain**: This is a relatively prominent early symptom of myeloma, manifesting as pain in the lower back, spine, pelvis, ribs, and other areas. The intensity of pain varies and may be migratory in nature, worsening with physical activity. 2. **Anemia**: Myeloma cells can interfere with the growth of normal hematopoietic cells, leading to reduced red blood cell production and symptoms of anemia such as dizziness, fatigue, and pallor. 3. **Renal dysfunction**: Myeloma cells may produce large amounts of abnormal immunoglobulins that must be metabolized and excreted by the kidneys, causing kidney damage. This may manifest as oliguria, facial edema, proteinuria, and other symptoms. 4. **Infections**: Myeloma can impair immune function, making patients more susceptible to infections such as respiratory tract infections and urinary tract infections. 5. **Other symptoms**: These may include fatigue, hemorrhagic tendencies, and symptoms related to hypercalcemia (e.g., arrhythmia, constipation). If similar symptoms occur, prompt medical consultation and professional evaluation are recommended for accurate diagnosis.