Can a "small three positives" result turn negative?
Due to my own health reasons, I am a hepatitis B virus carrier with the "small three positives" pattern. I would like to ask the doctor, is it possible for the "small three positives" to become negative?
Doctor's answer (1)
"Small three positives" refers to a condition following hepatitis B virus infection, characterized by positive results for hepatitis B surface antigen (HBsAg), hepatitis B e antibody (HBeAb), and hepatitis B core antibody (HBcAb). The clearance of hepatitis B virus typically refers to the disappearance of these markers or a reduction in viral load to undetectable levels.
It is possible for "small three positives" to achieve viral clearance, although the probability is relatively low. "Small three positives" is one clinical type of hepatitis B, and some patients may achieve viral clearance either through natural immune response or systematic antiviral treatment, particularly the clearance of surface antigen. The annual rate of natural clearance is approximately 1%, while systematic antiviral treatment can increase the clearance rate to 5%-10%. Due to individual differences, the process of viral clearance varies among patients, and personalized treatment plans should be developed based on individual conditions and under a physician's guidance.
Patients should regularly monitor their liver function and viral load, and follow medical advice for treatment and management.
