What are the side effects of tretinoin cream?

Tretinoin cream, as a commonly used dermatological medication, is primarily indicated for the treatment of acne, comedonal lesions, skin atrophy, and various keratinization disorders. However, its use is also associated with certain side effects. 1. Tretinoin cream may cause local skin irritation reactions, such as erythema, desquamation, and a burning sensation. These reactions are particularly noticeable at the beginning of treatment but usually gradually diminish or disappear within a few weeks. Patients with sensitive skin may experience more severe allergic reactions, such as pruritus, extensive erythema, and even blistering. 2. Tretinoin cream is metabolized through the liver and kidneys, and long-term use may increase the burden on these organs, potentially leading to hepatic and renal dysfunction. Additionally, this medication may cause other adverse reactions such as elevated blood lipid levels and palpitations. Therefore, tretinoin cream should be used only under the guidance of a physician to ensure appropriate and rational medication use. Attention should be paid to skin reactions and bodily changes during treatment. If severe discomfort occurs, the medication should be discontinued immediately, and medical attention should be sought. Moreover, pregnant women, women planning to become pregnant, and breastfeeding women should avoid using this medication to prevent potential adverse effects on the fetus or infant.