What are the causes of an elevated albumin/globulin ratio?

The main reasons for an elevated albumin/globulin ratio include the following aspects: 1. Physiological causes: In infants and toddlers under 3 years old, decreased synthesis of globulin may lead to a higher albumin/globulin ratio. This condition does not require special treatment and will normalize with age. 2. Hemoconcentration: Conditions such as dehydration, excessive sweating, or failure to replenish fluids promptly can cause hemoconcentration, significantly increasing albumin levels and consequently elevating the albumin/globulin ratio. 3. External intake: Oral consumption of large amounts of protein powder or intravenous administration of albumin preparations can increase plasma albumin levels, leading to an elevated albumin/globulin ratio. 4. Disease-related causes: Conditions such as primary hypogammaglobulinemia, systemic lupus erythematosus, and cirrhosis can lead to reduced globulin synthesis or disrupted albumin metabolism due to impaired liver function or abnormal immune function, thereby causing an elevated albumin/globulin ratio.