Olanzapine discontinuation after sudden cessation for two days resulted in withdrawal symptoms. Restless sitting and lying.

Jan 21, 2025 Source: Cainiu Health
Disease description:

I am a 45-year-old psychiatric patient who has been on long-term treatment with Zyprexa (olanzapine). Recently, I suddenly stopped taking the medication for two days due to certain reasons, and I am now experiencing withdrawal symptoms such as restlessness. What should I do?

Doctor's answer (1)
Dr. Zhang Baohua

Olanzapine is a commonly used antipsychotic medication for treating psychiatric disorders such as schizophrenia and bipolar disorder. Suddenly discontinuing olanzapine after long-term use may lead to a range of withdrawal reactions, including anxiety, irritability, insomnia, nausea, and dizziness. These symptoms may stem from the sudden changes in the drug's metabolism and mechanism of action within the body, disrupting the balance of the nervous system.

It is recommended to immediately contact a psychiatrist or pharmacist and explain the situation. They may suggest gradually resuming the medication or prescribe alternative drugs to alleviate the withdrawal symptoms. Additionally, maintaining regular sleep and eating patterns, engaging in moderate exercise, and practicing relaxation techniques such as deep breathing and meditation can also help relieve discomfort caused by discontinuation.