How serious is a uric acid level of 500 μmol/L?

A uric acid level of over 500 μmol/L has already exceeded the normal range, although it is not considered very severe, it still requires attention.

The normal reference range for uric acid is generally 150-416 μmol/L for males and 89-357 μmol/L for females. Elevated uric acid levels may be related to various factors, including diet, genetics, and metabolic abnormalities. When the uric acid level exceeds 420 μmol/L, it is often clinically defined as hyperuricemia.

Hyperuricemia may lead to various health problems. The most direct consequence is gout. Gout is a disease caused by deposition of urate crystals in the joints, characterized by acute arthritis attacks, presenting as severe joint pain, redness, swelling, and fever. In addition, long-term hyperuricemia may damage kidney function, leading to uric acid nephropathy or kidney stones, and may even increase the risk of cardiovascular disease.

For a uric acid level of over 500 μmol/L, it is recommended to initially lower the uric acid level through lifestyle modifications, such as reducing intake of high-purine foods, drinking more water to promote uric acid excretion, and maintaining a healthy body weight. If the uric acid level remains elevated or is accompanied by other symptoms such as joint pain or swelling, prompt medical consultation is advised. Follow medical advice regarding pharmacological treatment to control uric acid levels and prevent related complications.