Can I drink alcohol one week after taking cephalosporin?

Mar 18, 2025 Source: Cainiu Health
Disease description:

I had a sore throat a while ago and took cephalosporin antibiotics for a week. Now I feel much better. Since I just stopped taking the medication a few days ago, is it okay to have some alcohol tonight for an important social event?

Doctor's answer (1)
Dr. Shen Yonghua

Under normal circumstances, it is not recommended to consume alcohol one week after taking cephalosporins.

Cephalosporins may interact with alcohol, potentially causing a disulfiram-like reaction. This is a serious drug-alcohol interaction that may lead to symptoms such as facial flushing, dizziness, palpitations, and even shock. The occurrence of this reaction is related to the metabolism time of cephalosporins in the body. Typically, several half-lives are required for complete clearance of these drugs from the body.

Additionally, different types of cephalosporins have varying half-lives, so the time required for complete elimination from the body differs accordingly. Generally, for a period after discontinuation, the effects and components of cephalosporins may still remain in the body and interact with alcohol. Moreover, if the patient has impaired liver or kidney function, the metabolism of cephalosporins may slow down, prolonging their retention in the body. Therefore, alcohol consumption is not advised at this time.

After completing cephalosporin treatment, patients are advised to wait until the drug is fully cleared from the body and their physical condition permits before consuming alcohol in moderation.