What does it mean if cholinesterase levels are high?
A few days ago, my workplace organized a physical examination, and the results showed that my cholinesterase level was elevated. I usually maintain a regular lifestyle and haven't experienced any obvious physical discomfort. I just wanted to ask, what could cause an elevated cholinesterase level?
Doctor's answer (1)
Elevated cholinesterase levels may be caused by factors such as excessive nutrition, drug stimulation, liver disease, or endocrine disorders.
A high-protein diet or a state of overnutrition can also lead to increased cholinesterase levels. Certain medications, such as corticosteroids, may affect cholinesterase metabolism and cause elevated levels. The liver is one of the main sites of cholinesterase production, and conditions such as enhanced liver function or certain liver diseases may lead to increased cholinesterase levels.
Liver diseases such as fatty liver, hepatitis, and cirrhosis can damage liver cells and cause the release of cholinesterase, thereby increasing plasma cholinesterase levels. Endocrine disorders such as hyperthyroidism and diabetes, as well as neurological diseases, may also cause elevated cholinesterase levels. Cholinesterase elevation caused by these diseases requires timely evaluation and treatment.
In clinical practice, cholinesterase testing is commonly used to assess liver function, diagnose organophosphorus poisoning, and monitor treatment effectiveness in patients with myasthenia gravis. For individuals with elevated cholinesterase levels, a comprehensive assessment combining clinical symptoms and other laboratory test results is required, and when necessary, a specialized physician should formulate an appropriate diagnostic and treatment plan.
