Does taking rosuvastatin increase blood sugar levels?

Mar 24, 2025 Source: Cainiu Health
Disease description:

I'm taking Rosuvastatin due to high blood lipids. Recently, I've noticed my blood sugar levels seem somewhat unstable, and I'm not sure if it's related to the medication. I'd like to ask whether taking Rosuvastatin can truly cause elevated blood sugar levels?

Doctor's answer (1)
Dr. Liu Feng

Rosuvastatin is a commonly used lipid-lowering medication, available in various dosage forms such as tablets and capsules. Generally, blood glucose levels may increase after taking rosuvastatin.

As a widely used statin medication, rosuvastatin is primarily used to lower cholesterol and prevent cardiovascular diseases. After administration, rosuvastatin may interfere with insulin signaling pathways, reducing insulin sensitivity in muscle and fat tissues, thereby decreasing glucose utilization.

Long-term use may also have adverse effects on pancreatic beta cells, reducing insulin secretion. Additionally, rosuvastatin may affect hepatic glucose metabolism, increasing glycogen breakdown and gluconeogenesis, thereby releasing more glucose into the bloodstream. Therefore, rosuvastatin intake may lead to elevated blood glucose levels.

When prescribing these medications, doctors will comprehensively evaluate the patient's health status, including blood glucose control, to develop the most appropriate treatment plan. Patients should also regularly monitor their blood glucose levels during treatment and strictly follow medical instructions for medication use. At the same time, maintaining a healthy lifestyle, such as following a low-fat, low-sugar, high-fiber diet, can also help control blood glucose levels.