What does it mean if the blood turns purple after a blood draw?

Nov 25, 2022 Source: Cainiu Health
Dr. Yang Shuwen
Introduction
There are two situations in which blood appears purple. One is when the skin at the blood collection site turns purple. If discoloration occurs at the skin puncture site, it is likely due to incorrect pressure application, resulting in bleeding under the skin. The other situation is when the drawn blood itself appears purple. This happens because venous blood has lower oxygen levels and higher carbon dioxide content, giving it a darker appearance. Conditions such as high blood lipid levels or systemic hypoxia can also cause this phenomenon.

Blood turning purple after drawing can occur in two situations: one is discoloration to purple at the skin puncture site, and the other is the drawn blood itself appearing purple, with different underlying causes.

1. Skin Discoloration at the Puncture Site

If the skin around the blood draw site turns purple, it is often due to incorrect pressure application, leading to bleeding under the skin. It could also result from insufficient pressure duration. Since the needle used for blood collection is relatively thick, a noticeable puncture hole remains after withdrawal from the vein. Adequate pressure must be applied to prevent bleeding. Insufficient compression time may lead to subcutaneous bleeding, causing purplish bruising around the site.

2. Drawn Blood Appears Purple

1) Normal Condition

In some cases, drawn blood naturally appears darker, which may be normal. Venous blood has lower oxygen content and higher carbon dioxide levels. Oxygenated hemoglobin is bright red; therefore, deoxygenated venous blood appears darker in color.

2) Hyperlipidemia (High Blood Lipids)

Patients with hyperlipidemia have thicker, more viscous blood that circulates more slowly through vessels. After being drawn, their blood may appear significantly darker—almost purple. The higher the blood viscosity, the darker the blood color tends to be.

3) Systemic Hypoxia (Lack of Oxygen)

If arterial blood is drawn and appears purple, this may indicate systemic hypoxia. The patient should be evaluated for conditions such as asthma, lung diseases, or circulatory disorders.

If skin discoloration occurs, the bruise will typically fade over time as it is gradually absorbed. However, if the drawn blood itself appears purple, it is advisable to visit a hospital for further evaluation, obtain an accurate diagnosis, and receive appropriate treatment accordingly.