What does it mean when the red blood cell distribution width coefficient of variation is low?

A low red blood cell distribution width coefficient of variation (RDW-CV) usually refers to a reduced width of red blood cell volume distribution.

A low RDW-CV is generally caused by a decreased number of red blood cells in the patient's body, often due to hematologic disorders such as leukemia, aplastic anemia, or thalassemia. Prolonged physical depletion can also lead to reduced red blood cell counts, resulting in a lower RDW-CV. Chronic anemia or excessive blood loss may similarly cause a low RDW-CV; examples include postpartum hemorrhage in pregnant women and gastrointestinal bleeding. Under medical guidance, patients should appropriately supplement iron, such as with ferrous succinate tablets or ferrous sulfate tablets. Including iron-rich foods in the daily diet can also help support recovery.

Moreover, a low RDW-CV does not typically warrant excessive concern. However, it is important to seek timely medical evaluation and receive treatment based on the underlying cause.