The difference between clarithromycin and erythromycin
Apr 19, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Clarithromycin is a derivative of erythromycin. Clarithromycin dissolves in acetone or ethyl acetate, is slightly soluble in methanol or ethanol, and is insoluble in water. Erythromycin is readily soluble in methanol, ethanol, or acetone, and very slightly soluble in water. Clarithromycin is used to treat conditions such as tonsillitis caused by susceptible bacteria. Erythromycin is effective against atypical pathogens and diseases associated with Streptococcus pyogenes.
Clarithromycin and erythromycin differ in properties, physical characteristics, uses, and other aspects. A detailed analysis is as follows:
1. Different Properties
Both clarithromycin and erythromycin belong to the macrolide class of antibiotics, but clarithromycin is a derivative of erythromycin.
2. Different Physical Characteristics
Both clarithromycin and erythromycin appear as white or off-white crystalline powders with no odor, although erythromycin is slightly hygroscopic. Clarithromycin dissolves in acetone or ethyl acetate, is slightly soluble in methanol or ethanol, and is insoluble in water. Erythromycin dissolves readily in methanol, ethanol, or acetone, and is only very slightly soluble in water.
3. Different Uses
Clarithromycin is commonly used to treat diseases such as tonsillitis, pharyngitis, and rhinitis caused by various susceptible bacteria. Erythromycin primarily targets atypical pathogens, such as Mycoplasma and Chlamydia, causing pulmonary inflammation and bronchitis. It can also be used to treat conditions like tonsillitis and pharyngitis associated with pyogenic Streptococcus.
In addition, their contraindications differ. It is recommended to use these medications under the guidance of a physician to avoid adverse effects from self-medication.
