What Is Hepatorenal Syndrome?
Aug 09, 2021
Source: Cainiu Health
Dr. Wang Jihong
Introduction
Hepatorenal syndrome (HRS) is a progressive, functional renal failure that occurs in patients with severe liver disease in the absence of intrinsic kidney disease. It commonly develops in the terminal stages of chronic liver diseases, such as end-stage cirrhosis and liver failure. Clinically, it is characterized primarily by oliguria or anuria, decreased creatinine clearance, and dilutional hyponatremia. Its most distinctive feature is severe impairment of renal function despite the absence of structural kidney damage.
Hepatorenal syndrome (HRS) is a progressive, functional renal failure that occurs in patients with severe liver disease in the absence of intrinsic kidney disease. It commonly develops in the terminal stages of chronic liver diseases, such as end-stage cirrhosis and acute-on-chronic liver failure. Clinically, it is characterized primarily by oliguria or anuria, decreased creatinine clearance, and dilutional hyponatremia. The most distinctive feature is that, despite markedly impaired renal function, there is no evidence of acute tubular necrosis or other pathological abnormalities—or only minimal histopathological changes that are disproportionate to the severity of renal dysfunction.
