What is Tetanus Immune Globulin?

In daily life, accidental skin injury—especially deep wounds—may necessitate tetanus vaccination to reduce the risk of infection. What is tetanus immune globulin?

What Is Tetanus Immune Globulin?

Tetanus immune globulin (TIG) is prepared by extracting and inactivating plasma from healthy individuals who have been immunized with the tetanus vaccine. It is primarily used for the prevention and treatment of tetanus. TIG is administered when wounds are contaminated, particularly for patients allergic to tetanus antitoxin. Its protective effect is relatively short-lived—typically lasting about two weeks, and no longer than three weeks. Allergic reactions are extremely rare, and adverse effects are uncommon.

Tetanus immune globulin is an injectable preparation, officially termed “human tetanus immune globulin.” It is primarily indicated for the prevention and treatment of tetanus, especially in individuals allergic to tetanus antitoxin. Adverse reactions to TIG are generally absent; only a very small number of individuals may experience mild, localized reactions such as redness, swelling, or pain at the injection site. These symptoms typically resolve spontaneously without specific intervention. Administration is via intramuscular injection into the gluteal muscle, and no skin test is required prior to injection. The standard dose for both adults and children is 250 IU per administration, serving as a passive immunizing agent against tetanus.

In daily life, if tetanus immune globulin administration is required, it should be performed at a reputable medical facility. We hope this information is helpful to you.