Why does taking folic acid during pregnancy cause stomach pain?

Every woman planning pregnancy—or during the first three months of pregnancy—should take folic acid as part of a preventive strategy to reduce the risk of fetal congenital malformations. Some women may experience stomach pain after taking folic acid. So, why does stomach pain occur during pregnancy when taking folic acid?

Why Does Stomach Pain Occur When Taking Folic Acid During Pregnancy?

Stomach pain experienced during pregnancy while taking folic acid is generally not directly related to the supplement itself. Abdominal discomfort or pain is more commonly caused by damage or irritation to the gastric mucosa. Such symptoms are typically managed with oral medications that suppress gastric acid secretion and relieve pain. During pregnancy, traditional Chinese patent medicines (under medical guidance) may be considered for symptom management. Additionally, dietary adjustments are essential: avoid spicy, stimulating, fried, or greasy foods, which may exacerbate gastric irritation.

Folic acid is usually administered in low doses and is a water-soluble vitamin; it rarely causes side effects or gastrointestinal irritation. If stomach discomfort persists, consider switching to a different brand of folic acid supplement. However, if you already have an underlying gastric condition—such as gastritis or gastric ulcers—you may be more susceptible to gastrointestinal irritation upon folic acid intake, leading to discomfort. To minimize this risk, avoid taking folic acid on an empty stomach; instead, take it with or shortly after meals.

If stomach pain continues even when folic acid is taken after meals, consider switching to a prenatal multivitamin formulation, which contains an adequate amount of folic acid alongside other essential nutrients—and often causes less gastrointestinal irritation. Maintaining regular, balanced meals and ensuring comprehensive dietary nutrition also supports optimal absorption of other vital nutrients. We hope this information is helpful!