Why Do Dyshidrotic Eczema Blisters Develop?
May 18, 2022
Source: Cainiu Health
Dr. Liu Wan
Introduction
The pathogenesis of dyshidrotic eczema is typically associated with excessive sweating of the hands and feet, leading to sweat retention within the skin. It is also considered an endogenous, eczema-like cutaneous reaction. Additionally, dyshidrotic eczema may be strongly linked to psychological factors, local allergies or irritants, underlying foci of infection, systemic infections, and autonomic nervous system dysfunction. Moreover, dyshidrotic eczema not only causes localized skin damage but may also have broader implications.
Dyshidrotic eczema, also known as pompholyx or dyshidrosis, is a vesicular dermatosis affecting the palms and soles. So, what causes dyshidrotic eczema?
Causes of Dyshidrotic Eczema
The pathogenesis of dyshidrotic eczema is commonly associated with excessive sweating (hyperhidrosis) of the hands and feet, leading to retention of sweat within the epidermis. It is also considered an endogenous, eczematous skin reaction. Additional contributing factors include psychological stress, local allergic reactions or irritants, underlying foci of infection, systemic infections, and autonomic nervous system dysfunction. Moreover, if left untreated, dyshidrotic eczema not only damages localized skin but may also predispose to secondary infection. Recently, systemic allergic reactions triggered by certain metals—such as nickel and cadmium—have been recognized as potential triggers. Psychological factors are also a major contributor; many patients report exacerbation of symptoms during periods of emotional tension or anxiety.
Symptoms of dyshidrotic eczema: Characteristically, it presents as clusters of small, deep-seated vesicles located in the epidermis—approximately rice-grain sized, dome-shaped, and slightly elevated above the skin surface, without overt signs of inflammation. Lesions predominantly occur on the palms, lateral aspects of the fingers, and fingertips. The vesicular fluid is clear and translucent; upon rupture, the vesicles desquamate, revealing erythematous, newly formed epithelium.
Short-term oral prednisone therapy is often effective. Topical corticosteroid ointments may also be used. Additionally, herbal washes such as Gegen decoction (Pueraria root decoction) or Cangfu decoction (Atractylodes and Alisma decoction) can be applied externally. However, all treatments must be administered strictly under medical supervision. We hope this article has been helpful to you!
