What is the normal value of G6PD in pregnant women?

G6PD testing in pregnant women assesses glucose-6-phosphate dehydrogenase activity—not glucuronidase, as mistakenly stated. The normal reference range for G6PD activity is 1300–3600 U/L. G6PD deficiency is an inherited disorder. So, what is the normal G6PD value for pregnant women?

What is the normal G6PD value for pregnant women?

The normal G6PD activity range is 2600–4000 U/L. G6PD deficiency is an inherited hematologic disorder that typically remains asymptomatic and does not affect general health under normal conditions. However, exposure to certain oxidative triggers—such as fava beans (broad beans) or specific medications (e.g., aminoquinolines)—can precipitate acute hemolytic anemia, posing a direct threat to health and, in severe cases, endangering life. If a newborn is diagnosed with G6PD deficiency, close collaboration with healthcare providers is essential for managing physiological jaundice. Pregnant women diagnosed with G6PD deficiency should promptly consult their physician.

G6PD deficiency is not “fava bean disease” in the literal sense, nor is it related to poverty. Rather, it is an inherited metabolic disorder. G6PD is an enzyme present in human red blood cells and plays a critical role in glucose metabolism. During this metabolic process, NADPH—a key antioxidant—is generated, protecting red blood cells from oxidative damage. In individuals with G6PD deficiency, exposure to specific oxidants or ingestion of certain drugs can trigger red blood cell destruction, leading to acute hemolytic reactions.

If either partner is G6PD-deficient during pregnancy, low-dose supplementation with phenobarbital (not “benzene”), folic acid, vitamin E, and vitamin B complex may be considered starting four weeks before the estimated due date—only under strict medical supervision. We hope this information is helpful!